Behandlung von Ösophagus-Varizen bei Leberzirrhose Behandlung von Ösophagus-Varizen bei Leberzirrhose Carvedilol zur Senkung der portalen Hypertonie

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Blutungskomplikationen der portalen Hypertonie, Behandlung von Ösophagus-Varizen bei Leberzirrhose Syndrom, hepato-pulmonales Syndrom, hepatische Enzephalopatie, spontane bakterielle Peritonits und Aszites.

Use according to one of claims 1 to 3, wherein sildenafil, tadalafil or vardenafil can be used as PDE 5 inhibitor. Use according to one of claims 1 to 4 in combination with a substance selected from the group consisting of vasopressin and its source, and somatostatin, and analogs thereof.

The portal hypertension portal hypertension, ie, the high pressure in the portal veinamong others dreaded cause of bleeding from the upper gastrointestinal tract. The most common is bleeding from "oesophageal varices", ie varicose veins that develop in the esophagus because the flow of blood is impeded by the liver and the blood seeks a "detour circulation". Another problematic Bleeding complication of PH are fundal varices. Daneben sind weitere Komplikationen denkbar.

In addition, other complications are possible. Cormack und PA Mc. Cormick, Drugs The portal hypertension is a disease appearance with very complex and diverse etiology. Different from the cirrhotic portal hypertension as such may be a consequence of liver cirrhosis, as well as entirely different reasons, namely as a result of the following states: As chronic Behandlung von Ösophagus-Varizen bei Leberzirrhose leukemia, myelofibrosis Lymphatische Systemerkrankungen Lymphatic system disorders Kollagenosen z.

As systemic lupus erythematosus, scleroderma Kongenitale Leberfibrose Congenital hepatic fibrosis Leberfibrosen anderer Ursache Liver fibrosis from other causes M. Rechtsherzinsuffizienz Right heart failure Trikuspidalinsuffizienz Tricuspid regurgitation Pericarditis constrictiva Constrictive pericarditis Budd-Chiari-Syndrom Thrombosen der Behandlung von Ösophagus-Varizen bei Leberzirrhose Budd-Chiari syndrome thrombosis of the hepatic veins Fehlbildungen der Lebervenen Abnormalities of the hepatic veins Kompression der Lebervenen z.

Die bisherigen Prophylaxe- und Therapiekonzepte gegen die portale Hypertonie und speziell der Blutungskomplikationen weist keine ausreichende Erfolgsrate auf. The previous prophylactic and therapeutic approaches against portal hypertension and specifically in click at this page complications does not have sufficient success rate.

In addition, the portal hypertension lead learn more here numerous other diseases or medical complications.

Komplikationen zu erweitern und zu verbessern. This object is solved by the use according to any one of claims 1 to 2. Preferred refinements of the use according to the invention are defined in the dependent claims. As a basis for this new approach and improved treatment options has surprisingly been found that inhibitors of phosphodiesterase 5 are able to Behandlung von Ösophagus-Varizen bei Leberzirrhose portal vein and the portal vein diameter significantly to increase significantly.

Inhibitors that are specific with respect to the phosphodiesterase type 5 PDE-5 in humans currently are 11 known types of phosphodiesteraseare known per se, however. For other indications than Behandlung von Ösophagus-Varizen bei Leberzirrhose of the present invention.

The best known indication field is the male erectile dysfunction MED, impotence see Fig. Quinazolines with cGMP phosphodiesterase-inhibiting activity, such as are described in J. Med Chem HA Ghofrani et al.

Behandlung von Ösophagus-Varizen bei Leberzirrhose 56, describe Sildenafil for treatment of pulmonary hypertension and possibly also the beginnings of heart insufficiency.

Especially in the case of the ascites is a combination of a PDE 5 inhibitor with any diuretic Furosimid example example of a loop diuretic or spironolactone an aldosterone antagonistparticularly suitable. Sildenafil INNdh As PDE 5 inhibitors known per se from the above-mentioned documents PDE 5 inhibitors and the particular selectivity for PDE 5 against other phosphodiesterases, the following compounds suitable for use in the invention: The PDE 5 inhibitor according to the Behandlung von Ösophagus-Varizen bei Leberzirrhose is preferably used as a single agent, optionally in combination with conventional drugs to reduce portal pressure.

Because the effects supplement each other, fiction, can Behandlung von Ösophagus-Varizen bei Leberzirrhose be carried out in accordance with a combination by using, in a common or in separate formulations of the Please click for source 5 inhibitor in combination with a substance selected from the group consisting of vasopressin and its analogues such as terlipressin and somatostatin and its analogues, such as octreotide, in order to additionally contribute by an increase in the arterial vascular resistance to decrease of the arterial blood supply to the intestine and liver.

Der Wirkstoff oder die Zusammensetzung kann. The active Behandlung von Ösophagus-Varizen bei Leberzirrhose or the composition may. The compositions suitably contain an effective therapeutic amount of PDE5 inhibitor together with a suitable amount of a click at this page or vehicle to provide the form for proper administration to the patient.

The application form can be a typical application form, for example контейнере Varizen Grad 1 Foto Синий, parenterally, in particular for injection, such as intravenous or intra-arterial injection, a transdermal, nasal or inhalation. For acute hemorrhages particularly intravenous iv injections of a PDE 5 inhibitor and preferably in combination with a vasopressin or somatostatin or derivatives thereof.

For application, the PDES inhibitor and optionally the mentioned combination therapeutics are suitably present in one of the ge above-mentioned compositions, formulations or facilities in an amount, based on the total amount of at least 0.

As the dose is an amount of the active ingredient of at least 0. The specific activity of PDE 5 inhibitors for the indications listed above, special is as follows: Portale Hypertonie, Portal hypertension.

In a pilot study, a significant increase in the diameter of the portal vein and the splenic vein was found. The maximum flow rate of blood in the portal vein and splenic vein in the decreased only slightly.

Due to the rapid just click for source response and the generation of the effect "reduction in portal pressure" after taking the PDE 5 inhibitors also a therapy of acute bleeding complications is possible -kurzzeitig directly or indirectly. This disease represents a deterioration of renal function with a regulatory disorder, although the kidney itself is intact.

The conventional therapy, namely volume administration, Behandlung von Ösophagus-Varizen bei Leberzirrhose of albumin or of terlipressin is not continue reading. According to the Behandlung von Ösophagus-Varizen bei Leberzirrhose 5 inhibitors, the blood flow is enhanced by the liver through the use of PDE, so that it is expected that blood from the portal vein supplied to the systemic circulation, and thus an improvement of the hepato-renal syndrome is expected.

This disease is associated with portal hypertension and arterial oxygen desaturation. Symptoms include shortness of breath and decreasing performance. It come here for short connections between the branches of the pulmonary artery and the pulmonary veins.

Daher wird das sauerstoffarme Blut teilweise nicht wieder in der Lunge mit Sauerstoff angereichert. Therefore, the oxygen-poor blood is partially not replenished again in the lungs with oxygen.

The inventive reduction in portal pressure and thus the positive effect on the hypertension Behandlung von Ösophagus-Varizen bei Leberzirrhose is an improvement of the hepato-pulmonary syndrome expected.

This disease is also associated with portal hypertension disease condition with non-inflammatory brain damage or disease. Again, a significant positive effect is expected because less Behandlung von Ösophagus-Varizen bei Leberzirrhose to the liver River crosses marked improvement in hepatic blood flow.

Aszites und spontane bakterielle Peritonitis: Ascites, spontaneous bacterial peritonitis: By lowering the pressure in the portal vein system, the condition of ascites will improve as expected. The invention is explained in more detail below by means of representative examples by use of an exemplary PDE 5 inhibitor. Danach wurden pro Proband mg Sildenafil oral verabreicht. Then mg of sildenafil per subject were administered orally.

Im Durchschnitt 90 Min. On average, 90 min. After taking this drug, the measurements were repeated. The measurement parameters and the results они Medikamente für Krampfadern Bewertungen что summarized in the table below.

Die Ergebnisse zeigen eine geringe Absenkung des arteriellen Blutdrucks und eine deutliche Zunahme des Durchmessers von Pfortader und Milzvene. The results show a small reduction in arterial blood pressure and a significant increase Behandlung von Ösophagus-Varizen bei Leberzirrhose the diameter of portal vein and splenic vein.

Die maximalen Flussgeschwindigkeiten des Blutes in der Pfortader bzw. In contrast, Behandlung von Ösophagus-Varizen bei Leberzirrhose flow of blood increased by From this it can be concluded that a reduction of pressure in the portal vein when administering an effective amount of a representative 5 inhibitor.

Treatment of erectile dysfunction using new or known imidazo 1,5-a pyrido 3,2-e pyrazinones as phosphodiesterase inhibitors, some of which are also useful for treating cardiovascular disorders. Pharmaceutical formulation containing pyrazolo[4,3-d]pyrimidine and nitrates or thienopyrimidines and nitrates. Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee.

Sie treten vor allem bei Leberzirrhose auf und sind Abnehmbare Minikreisligation ist nützlich für die endoskopische Behandlung von Ösophagus-Varizen.

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